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Researchers have developed a new NIR laser 3D printing technology using gold nanorods to control biological printing

Abstract: at present, a groundbreaking new technology is being tried for biological 3D printing, which may completely change the design method of biological tissue. The post-processing technology of new materials also affects the VOC emission of interior parts. The new method developed by researchers at the National University of Singapore involves using laser technology to control the micro environment of cell culture development to a higher degree, which provides a wide range of advantages for the improvement of final products

at present, a groundbreaking new technology is being tried out for biological 3D printing, which may completely change the design method of biological tissue. The new method developed by researchers at the National University of Singapore involves using laser technology to control the micro environment of cell culture development to a higher degree, which provides a wide range of advantages for the improvement of final products

generally, biological 3D printing involves implanting cells into micro scaffold like structures, where they can replicate and eventually form new tissues in a manner directed by the biological engineer who designed the scaffold. However, this method has some shortcomings and limitations. Cells can be produced at a very low density, but the proliferation of cells in the body may be very slow and uneven

researchers have proposed and tried a number of other methods, including the use of microfluidic processes or the use of magnetic or robotic technology to control cell replication. Most of these so-called "top-down assembly" processes also have some limitations, such as limited material selection and limited biocompatibility

a successful new option is lightweight technology, which usually uses high-intensity lasers called "optical tweezers", which can provide a high level of control over the manipulation of objects on a micro scale. The laser is controlled by an automatic motor and programmed with a virtual 3D model, which guides the replication of cells into the desired structure or pattern. The problem with this method is that the high power of the laser may cause damage to the biological sample pool

the ideal solution is to use the photoconductive assembly technology of relatively low-power lasers for 3D printing tissue. Researchers have recently conducted some promising research, indicating that this is a possibility. The innovative research projects of complex experiments such as open-loop loading and unloading were carried out by Dinh Ngoc duy, Rongcong Luo Maria tankeh Asuncion Chris "23 tier cities are equipped with a full set of auxiliary weights tine, Weikang Nicholas Lin, Wei Chuan Shih, James Cho Hong Goh and Chia hung Chen PhD. The National University of Singapore published the results of 3D printing of stem cell loaded microgel with a new near-infrared (near-infrared excitation) method in the famous journal" Wiley ", and also submitted a U.S. patent

the team's innovation is to use gold nanorods (GNRs) incorporated into the microenvironment. The presence of these metal rods means that more light is absorbed from the laser and then converted into heat. Due to the improved heat absorption performance provided by gold nanorods, the use of lower intensity lasers can provide more control over the structure and integrate different building units

in order to test the improved accuracy and integration of different units, special hydrogels were used. The absorbed heat energy generates convection in the hydrogel, and controlling the direction of these thermal convection can build a specific structure. By guiding the laser, particles can be assembled in a specific way without any kind of support

in addition, the hydrogel particles inoculated with mesenchymal stem cells were prepared as functional building blocks to construct scaffold free tissue with the required structure. In this case, the "building block" of the structure is the stem cells in the hydrogel, and the NIR method enables the biological structure to be successfully constructed in the microenvironment in a short time

low laser intensity NIR method can better control the direction of convection without sacrificing the "throughput" of different applications, and the damage to biological samples is small. As a "golden tool" in surgery, NIR laser may work in an unprecedented way of 3D printing. The unprecedented accuracy provided by technology means that it can have a wide range of applications, not only bioprinting, but also regenerative medicine, tissue engineering and advanced manufacturing